Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome, gene 1(English)

• an orphan nuclear receptor acting as a suppressor of Ad4 binding protein/steroidogenic factor 1 [Ad4BP/SF-1 (NR5A1)] and as an anti-Sry factor in the process of gonadal sex differentiation. The roles of these nuclear receptors in the differentiation of the gonads and the adrenal cortex have been established through studies of the mutant phenotype in both mice and humans. Also denoted as DAX1
• DAX1, LKO, MKO, NF-kB
• Genetics
• https://doi.org…10/me.2002-0362
• https://doi.org…0/ijms232214009