drug-induced acute interstitial nephritis(English)

• represents a high percentage of acute renal failure in clinical practice.The mechanism by which the kidney injury occurs is due to hypersensitivity to the drug which elicits a cellular immune response. This reaction causes an interstitial infiltration of T lymphocytes, monocytes, plasma cells, and eosinophils, and at the systemic level, the appearance of cutaneous rash, arthralgia fever, eosinophilia, and occasionally, an increase in hepatic enzymes. In addition to this, in the sediment eosinophiluria can appear as a result of the tubulo-interstitial inflammatory injury
• NSAID
• Nephrology
• https://doi.org….2.5174.en.full