junctional protein associated with coronary artery disease(English)

• a membrane-associated protein, mainly expressed by endothelial cells, mediating the endothelial response to acute hypoxia in the brain through the PI3K/Akt pathway. Previously known as Junctional protein associated with Coronary Artery Disease or KIAA1462) is a protein highly expressed in vascular endothelial cells of systemic and cerebral arteries. Genetic studies demonstrated that single nucleotide polymorphisms in the human KIAA1462 gene are associated with coronary artery disease
• HBMVEC, I/R, NIHSS, PI3K, siRNA, TEER, tMCAO, TTC, VCAM, VE-cadherin, AD, AIS, AKT, BBB, CAD, CRP, CVA
• Cerebrovascular event, Coronary circulation, Pathology
• https://doi.org…bts.2024.10.005
• https://doi.org…bts.2024.09.009