negative vitamin D response element(English)

• bound by either VDR homodimers or by VDR/RXR heterodimers and subsequently downregulated. A second type of nVDRE, composed of E-box type motifs (5'–CATCTG–3'), was identified in the promoters of the human CTP27B1 gene, the human PTH gene, and the human PTHrP gene. These nVDREs are bound by a helix–loop–helix transcription factor known as VDR-interacting repressor and are transcriptionally active in the absence of 1,25(OH)2D3
• VDRE, VDR, RXR, PTH
• Transcription
• https://doi.org…78630-2.00396-0