Angiotensin-Converting Enzyme-2 receptor(English)
- ACE2 is a dominant mechanism for negative regulation of the RAS by metabolizing Ang II into the beneficial peptide Ang 1–7, and this important biochemical and physiological property is being harnessed as a potential therapy in patients with HF. The activation of the RAS axis due to binding of SARS-CoV-2 to ACE2, leading to direct loss of ACE2 and indirectly via proteolytic processing and shedding, partly drives the systemic manifestations of COVID-19. Careful targeting of the RAS axes is needed in these patients to optimize their clinical outcomes, including the use of AT1 receptor blockers (ARB)
- COVID-19, rhACE2, ARB, CVD, AT1, HF, RAS
- Receptors, Physiology, Biochemistry
- https://doi.org…SAHA.120.317015
- https://doi.org….1002/ejhf.2534
- https://doi.org…155/2012/256294