IBM

There are multiple definitions:

  1. inclusion body myositis(English)

    • one of the most common disabling idiopathic inflammatory myopathies among patients older than age 50. Presents with slowly progressive, distal and proximal muscle weakness, often with years from onset of symptoms to diagnosis. Early signs of the disease include asymmetric quadriceps and wrist/finger flexor weakness. At least 40% of patients complain of dysphagia. Not associated with cardiac abnormalities or any increased risk of cancer. The muscle biopsy demonstrates inflammation with atrophic fibers and eosinophilic cytoplasmic inclusions. Patients do not significantly improve with immunosuppressive therapy
    • sIBM
    • Musculoskeletal system, Inflammasome, Disability
    • https://www.mda…n-body-myositis
    • https://doi.org…-2787-6.00009-7
    • https://doi.org…b013e32833f0f4a
  2. interactive biopsychosocial model(English)

  3. inner boundary membrane(English)

  4. (inhibitor of apoptosis protein)-binding motif(English)