isocitrate dehydrogenase 1(English)
- a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, producing nicotinamide adenine dinucleotide phosphate (NADPH) within the citric acid cycle. This reaction is essential for cellular metabolism and antioxidant defense in neural cells
- MEIS1, NPM1, PRC2, SDH, TCA, TET, NADPH, α-KG, 2-HG, 5hmC, 5mC, AML, ASXL1, AZA, CMML, DAC, DNMT3A, DNMTi, DOT1L, EZH2, FH, HDAC, HDACi, HOXA9, HSC, IDH2, JARID2, JmjC, MBM, MDS, MLL, MPN
- Enzymes, Metabolism
- https://www.sci…dehydrogenase-1
- https://doi.org…rsl.2014.04.012