There are multiple definitions:
normal tissue complication probability(English)
- model that can be used for treatment plan optimization and patient selection for emerging treatment techniques, applicable in the field of radiotherapy to estimate the risk of radiation-induced complications, while aiming to translate radiation dose distributions, in combination with patient, disease and treatment characteristics, into a predicted probability that a complication will occur. Models should: (1) have adequate predictive performance in terms of calibration, the agreement between predicted probabilities and observed outcome (i.e. complication) frequencies, and in terms of discrimination, the ability of the model to distinguish between patients with and without the outcome; and (2) accurately describe the effects of radiation dose to normal tissues and the risk of complications, rather than reflect a mere correlation between radiation dose and complications. Challenges concern missing data, non-linear response relationships, multicollinearity between predictors, overfitting, generalizability and prediction of multiple complication grades at multiple time points
- Radiotherapy /radiation, Model(ing), Personalized approach, Decision making
- https://doi.org…onc.2020.04.012
Na(+)-taurocholate cotransporting polypeptide(English)