RNA-dependent RNA polymerase(English)

• one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences. The catalysis involves the participation of conserved aspartates and divalent metal ions. Complexes of RdRps with substrates, inhibitors and metal ions provide a comprehensive view of their functional mechanism and offer valuable insights regarding the development of antivirals
• RNA, IBV, PTGS
• Virology, Genomics, Transcription
• https://dx.doi.….3390/v10020076