troponin activator 1(English)

• a myotrope that increases myocardial contractility by sensitizing the sarcomere to calcium without impairing diastolic function or depleting the cardiac energy reserve. Its structure is identical to that of CK-136 (formerly known as AMG 594) with the noted exception of the replacement of the nitrogen in the 3-(methylsulfonyl)pyridine moiety of CK-136 with a carbon atom in TA1
• ATP, cAMP, HF, HR, LVEDP, PCr, RPP
• Myocyte / muscle, Cardiology
• https://doi.org…LURE.121.009195