tripartite motif-containing protein 5, α isoform(English)

• a retrovirus restriction factor with 493 amino acid E3 ubiquitin ligase expressed by cells of most primates. In humans it is one of a cluster of eight TRIM genes on chromosome 11. There is evidence for positive selective pressure in the cluster and several TRIM genes have been identified as viral restriction factors. Depending on the viral protein targeted, restriction can take place at different points in the virus replication pathway including entry, transcription, or release
• TRIM
• Gene cluster, Virology
• https://doi.org…03109-4.00006-4