MERS-CoV lacking the genes for 4a and 4b(English)
- removal of the gene coding for 4a and 4b proteins in the viral genome of this mutant strain induces the phosphorylation of eIF2a, activation of PKR and reduces viral replication in HeLa cells suggesting that these proteins are involved in circumventing translational attenuation during infection, suggesting a cell line specific regulation rather than a solid feature of MERS-CoV infection
- MERS, HeLa, PKR
- Virology
- https://doi.org…93/nar/gkaa1116
- https://doi.org…28/JVI.00902-18