There are multiple definitions:
mitochondrial permeability transition pore(English)
- a non-selective, high-conductance channel that forms in the inner mitochondrial membrane under pathological conditions like high calcium ( ), oxidative stress, and ATP depletion. Its sustained opening triggers mitochondrial swelling, membrane depolarization, and cell death (necrosis/apoptosis), playing a key role in ischemia-reperfusion injury and neurodegenerative diseases Also denoted as mPTP
- BI-1, Ca2+, CHD, DCM, IPC, IPost, I/R, RISK, ROS, STZ
- Mitochondrion, Cardiology, Calcium, Channelopathy
- https://doi.org…era.2007.06.005
- https://doi.org…0/cells12091273
- https://doi.org…1002/ame2.70225
1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(English)
- is transformed to MPP+ via monoamine oxidase B (MAOB), which causes oxidative stress and destroys dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) and is widely used to create animal models of Parkinson’s disease
- MAOB, MPP, NOS, SNc
- Parkinson, Model(ing), Biochemistry, Mitochondrion
- https://doi.org…pnas.81.14.4591