methionyl aminopeptidase 1(English)
- Mendelian randomization reveals a significant association between its higher genetically predicted expression in aortic and tibial arterial tissues and greater risk of preeclampsia. METAP1 overexpression in human umbilical vein ECs decreases angiogenesis, with a 66% decrease in tube formation (P=7.9×10−3) and 72% decrease in cell proliferation (P=2.9×10−2). Furthermore, its overexpression decreases VEGFA expression and increased expression of multiple preeclampsia-related genes, for example, FLT1, INHBA, and IL1B
- FLT1, INHBA, IL1B, PE, PlGF, VEGFA, CD144, EC
- Hypertension, Pregnancy, Vascular disease, Pathology
- https://doi.org…SAHA.124.324606