metabolome-wide association study(English)

• the concept of this partadigm is straightforward: to extensively genotype or haplotype large human population cohorts and statistically link specific allelic or other genotypic variation to epidemiological data on, for example, body mass index, cardiovascular disease incidence, and diabetes, that were collected simultaneously. This approach has proved highly successful for the detection of common variants associated with a range of diseases and intermediate phenotypes. Any MWA-generated putative biomarker is connected by a complex physiological chain to factors that are known to link to regulation. Therefore, the approach can lead directly to novel, testable physiological questions that relate to disease risk, and may give new insights into disease mechanisms and pathophysiology that may ultimately lead to novel drug targets
• MWA, PWA, SNP, MGWA, AAS, ABP, BBQ, EBP, ERC, GC-MS, MRR, WADA
• Genomics, Metabolism, Epidemiology, Regulation / control, Sports medicine, Addiction and health, Biomarker, Forensic medicine
• https://doi.org….1021/pr8005099
• https://doi.org/10.1002/dta.3250