post-vaccination geometric mean titer(English)

• serological parameters intend to describe antibody response to influenza vaccine in a population. However, there is uncertainty about the mathematical appropriateness and the biological or clinical meaning of conventionally used parameters. In a population seronegative before vaccination, the post-vaccination geometric mean titre is a meaningful immunological parameter adequately expressing antibody response after vaccination. Although not devoid of theoretical limitations (heteroscedasticity), correction of post-GMT and PR by linear regression appears to provide better estimates of antibody response and vaccine immunogenicity
• GMT
• Vaccination
• https://doi.org…res.2004.02.024