Shiga toxin(English)

• one of the most potent biological poisons known, found in Shigella dysenteriae 1 and in some serogroups of Escherichia coli (called Stx1 in E. coli). Consists of two major subunits, an A subunit that joins noncovalently to a pentamer of five identical B subunits. The A subunit of the toxin injures the eukaryotic ribosome, and halts protein synthesis in target cells. The function of the B pentamer is to bind to the cellular receptor, globotriaosylceramide, found primarily on endothelial cells. The Stxs traffic in a retrograde manner within the cell, such that the A subunit of the toxin reaches the cytosol only after the toxin moves from the endosome to the Golgi and then to the endoplasmic reticulum
• STEC
• Toxicology, Bacteriology
• https://doi.org….EHEC-0024-2013